Unconventional steroid signaling in the choroid plexus: implication in traumatic brain injury

Project Start Year
2020
Project Area of Research
Project Description

Choroid plexus (CP) epithelia main function consists in producing and regulating cerebrospinal fluid (CSF). Such regulation is achieved through transepithelial solute transport via plasma membrane ion channels and transporters. Interestingly, steroids and specially progesterone has been shown to exert potent neuroprotective action. Since fluid secretion in CP is under control of ion channels and transporters, we aim to explore whether progesterone can modulate Transient Receptor Potential channel activity directly in an unconventional manner meaning a rapid non-genomic way. The outcome of this research may be of interest for treatment of CSF malfunctions such as traumatic brain injury.

UC PI
Polina Lishko
Polina Lishko
Department of Molecular & Cellular Biology, UC Berkeley
France PI
Dmitra Gkika
Dmitra Gkika
Laboratoire de Physiologie cellulaire, Université de Lille - Sciences et Technologies