We propose to address fundamental questions related to aging of hematopoietic stem cells, which give rise to all cells of the immune system. We aim to understand how hematopoietic stem cells lose their functional capacity to support the immune system during aging and explore the therapeutic potential to reverse the degeneration and dysfunction of the aging immune system. Successful completion of these studies will reveal key factors that play paramount roles in maintaining stem cell homeostasis and tissue integrity during the aging process, and suggest new approaches to improve the immune function in the aged population.
UC PI:
Danica Chen
Department of Nutritional Sciences & Toxicology, UC Berkeley
French PI:
Mélanie Hamon
Unité des Interactions Bactéries-Cellules, Institut Pasteur - Paris
