The piperidine moiety is prevalent in a wide range of medicines that address human ailments. Despite the well-established efficacy of piperidine-containing drugs, there is a continued need to identify derivatives that possess even more potency and selectivity to overcome challenges such as side-effects. The introduction of substituents on the piperidine skeleton in these medicinally-active small molecules can imbue them with novel or more pronounced activity and selectivity. In this collaboration, we propose a way to derivatize piperidines at one of the resident C–H groups on the periphery of the carbon framework in a process referred to as C–H functionalization in order to access myriad derivatives.
UC PI:
Richmond Sarpong
Department of Chemistry, UC Berkeley
France PI:
Virginie Vidal
Chimie ParisTech, CNRS