The gut microbiota provides number of beneficial functions to its host, including nutrition, immune system regulation and niche protection against pathogens, and in return, the host shapes the environment to ensure commensal bacteria provide benefit. To maintain this ecosystemic symbiotic interactions at the organ scale, a myriad of microscale interactions occurs, between bacteria, or between the host and the microbiota. Data at different scale and resolution must be articulated to decipher these ecosystem-wide regulation mechanisms. This project aims at building an appropriate multidisciplinary methodology, gathering mathematical and experimental models, to enhance data integration and to identify new mechanisms involved in the gut microbiota regulation.
UC PI:
Andreas Bäumler
Medical Microbiology and Immunology, UC Davis
France PI:
Simon Labarthe
MaIAGE (MIA), INRA, Centre de Jouy-en-Josas