Liquid-phase transmission electron microscopy imaging of 3D structure and dynamics of human innate immune protein interactions in solution

With the complementary expertise of the Berkeley and France teams, we propose to implement liquid-phase transmission electron microscopy (LTEM) and individual-particle electron tomography (IPET) techniques, developed inhouse by the Berkeley team, to study France team long-term focused immune proteins and their interactions.

UC PI:
Gang (Gary) Ren
Molecular Foundry, Lawrence Berkeley National Laboratory

France PI:
Wai Li Ling
Département de Biologie Structurale et Cellulaire intégrée/Institut de Biologie Structurale, Université Grenoble Alpes