Exact Science

Photo-Generated Molecule-Based Magnets

David Harris
Rodolphe Clérac
2020

This project aims to develop molecule-based permanent magnets through a combination of chemical synthesis and photomagnetism. This work will leverage and combine the expertise in the synthesis of molecule-based magnets of co-PI Dr. D. Harris, a project scientist at the University of California, Berkeley (UCB), with the expertise in photomagnetism of co-PI Dr. R. Clérac, a CNRS researcher at the Centre de Recherche Paul Pascal (CRPP) in Bordeaux, France. Graduate students at UCB and CRPP will form the core of this effort, with the requested funds supporting student and PI exchanges...

Langlands duality and spectra of quantum integrable systems

Edward Frenkel
David Hernandez
2020

The category of finite-dimensional representations of a quantum affine algebra is one of the most studied objects in quantum groups theory with remarkable applications in various branches of Mathematics and Physics. However many important and fundamental questions remain unsolved in this field. The aim of this research project is to make advances in the understanding of the category as well as of its applications to quantum integrable systems and in the context of the Langlands program.

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Cylindric Partitions

Sylvie Corteel
Jérémie Bouttier
2020

This research project is at the interface between enumerative combinatorics and mathematical physics. It is centered on cylindric partitions, which are combinatorial objects that are connected with different fields: hypergeometric identities, string theory, probability theory and nonequilibrium statistical physics.

Sylvie Corteel

UC PI:
Sylvie Corteel
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Quantum Coherence in Molecular Heavy Element Clock Qubits

Stefan Minasian
Grégory Nocton
2022

This work will harness the unique electronic structures of heavy elements to create and control quantum coherent properties in atomically precise molecular spin qubits. Nocton is an expert in inorganic synthesis and electronic structure and will supply the novel ligands developed in his labs at École Polytechnique. Minasian will provide access to unique radioisotopes, facilities at Lawrence Berkeley National Laboratory (LBNL) for heavy element research, and characterization including synchrotron radiation, EPR, and magnetometry. We expect this new collaborative...

Genetic, genomic, and functional evolution of genes encoding viral-interacting proteins in great apes

Peter Sudmant
Lucie Etienne
2021

We propose a collaborative and integrative approach to identify and characterize selective signatures indicative of host-pathogen evolutionary conflict in diverse human and great ape populations and species. The Sudmant lab has extensive expertise in genomics and genetics and the Etienne Lab is expert in virus-host interaction and coevolution. Thus, collaboratively our groups are uniquely poised to address the critical scientific questions surrounding the adaptation of great apes to viral infection.

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Mapping coastal intertidal ecosystem primary production: coupling remote sensing and atmospheric eddy covariance

Dennis Baldocchi
Vona Méléder
2021

Intertidal coastal ecosystems (i.e. mudflats, salt marshes, seagrass beds, etc.) are present all over the world; they are often neglected in the global carbon budget, while these ecosystems are increasingly recognized to be as productive as tropical forests. Despite their potentially high contribution to the overall carbon budget, their actual contribution remains unknown. Moreover, these ecosystems are currently under threat from global changes and human activities. In this context, estimating the actual carbon uptake by these ecosystems is a challenge that has to be tackled, which...

Investigating the diversity and distribution of fungal viruses in soil

Joanne Emerson
Christina Hazard
2021

This project will leverage expertise in soil viromics and root-associated arbuscular mycorrhizal fungi to investigate fungal viruses in Mediterranean grasslands. The UC Davis team will visit Lyon to learn field and laboratory methods for identifying, collecting, and analyzing grassland fungi, including protocols for purifying fungal communities from roots and soil. Both teams will apply these approaches to their local grassland soils, which will be sequenced for the recovery of fungal viruses. The ECL team will then visit Davis to learn bioinformatics approaches for analyzing the...

Tracer-informed critical zone modelling to connect water ages with hydrological resources and solute exports

Matthias Sprenger
Sylvain Kuppel
2021

The project aims to reveal how water, and the chemical compounds it contains, are stored and released in the mountainous region of the Upper Colorado River. We will use the extensive sets of field observations collected for several years by the Lawrence Berkeley National Laboratory in the East River headwaters, in a novel combination with state-of-the-art numerical simulations of the processes through which water, plants and underground chemistry interact in these landscapes. In addition to advancing our knowledge on water resources, the proposed data-model integration will serve as...

Liquid-phase transmission electron microscopy imaging of 3D structure and dynamics of human innate immune protein interactions in solution

Gang (Gary) Ren
Wai Li Ling
2022

With the complementary expertise of the Berkeley and France teams, we propose to implement liquid-phase transmission electron microscopy (LTEM) and individual-particle electron tomography (IPET) techniques, developed inhouse by the Berkeley team, to study France team long-term focused immune proteins and their interactions.

Gang (Gary) Ren

UC PI:
Gang (Gary) Ren
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Structural dynamics of oxidoreductases crucial for the survival of human pathogens

Jan Kern
Hugo Lebrette
2022

In this project, we aim to study catalytic intermediates in two metal dependent oxidoreductases that both utilize dioxygen (O2) to catalyze reactions essential to various human pathogens. To capture intermediates, we want to employ a novel technique where we perform in situ enzyme activation with O2 gas at room temperature and use time resolved X-ray crystallography coupled with X-ray spectroscopy at an X-ray free electron laser. Using this approach, we will obtain detailed information about changes in the geometry and in the electronic structure of the metal site, and...